kjn830113 Spine uses the position of guides to determine the 0,0 origin within the editor. The first horizontal guide determines the y, while the first vertical guide determines the x. In the absence of horizontal and/or vertical guides, respectively, half of the width and half of the height will be used.
Also, you can use the origin tag. Name a layer [origin] and place a marker (e.g., an X) to define the origin.