Yes, it is possible to integrate Spine animation effects on widgets in Unreal Engine 5. The spine-ue runtime provides a Spine widget for UMG UI, which allows you to integrate Spine skeletons with your UI. You can add a Spine widget to your UMG UI by creating a new widget blueprint, adding the Spine widget via the palette, and setting the atlas and skeleton data asset on the widget. This setup allows you to use Spine animations within your Unreal Engine 5 projects.
For more detailed instructions, you can refer to the spine-ue Runtime Documentation.
